Welcome back to Mastering Medicinal Chemistry - year six! This conference continues to offer a quality, broad spectrum medicinal chemistry program with a strong chemistry flavor delivered through case study, poster and discussion group format. 

This year’s program will feature early- to late-stage programs across the therapeutic spectrum, including the most aggressively pursued targets within each group. Fragment-based design and screening approaches are becoming an integral part of the medicinal chemistry approach and will be featured extensively. An overall analysis of outsourcing chemistry activities will be featured in-depth, as well as discussion groups on solubility, the blood-brain-barrier and much more.

See you in San Francisco!

Edel

PROGRAM OUTLINE

• Chemistry Centric Case Studies (structures shared) Across Several Topical Therapeutic Areas Including:

  • Alzheimer’s Disease

  • Pain

  • Oncology

  • Diabetes & Obesity

  • Infection & HIV

• Examples from Pre-Clinical through Phase I, II and III (Pharma & Biotech)

• Coverage of The Industry’s Aggressively Pursued Targets from each Therapeutic Area Including:

  • Gamma-secretase, BACE

  • TRPV1, CB1, Bradykinin, P1, P2X3 & P2X7, Nicotinic Receptors

  • HDAC, c-Met, HER-2, VEGF, Topoisomerase I&II, TNF-alpha

  • DPPIV, GLP-1, HSD1, MC3/MC4

  • Gag & pol polyprotein processing enzymes, HCV

• Fragment-based Inhibitor Design, Screening and Optimization

  • How successful has FBDD been as a platform for medicinal chemistry – case studies

  • How has FBDD inspired fresh approaches in lead generation (small, soluble)

  • Special focus on optimization of fragment hits

  • Technology in support of FBDD

  • Facing the challenge of applying FBDD when structural information is not available

• Outsourcing Chemistry – The Benefit to Biotech and Big Pharma 

  • Insights on strategies across different organizations

  • How is it impacting the growth of Biotechs?

  • How successful is this activity from the management perspective?

  • How is this working for the bench chemist?
    

• Panels & Discussion Group Topics:

  • Solubility/ADME/ Permeability, Polar Surface/BBB

  • The Trouble with Kinases – Solubility for a Start

  • Medicinal Chemistry in Biotech Today

  • Outsourcing Chemistry

  • Novel Synthetic Strategies – In house and Outside
    

If you would like to submit a proposal to give a presentation or display a poster at this meeting, please submit a title and brief, 3-5 sentence summary of a proposed topic on your recent work in the area of the medicinal chemistry. 

All proposals are subject to review by the Scientific Advisory Committee to ensure the highest quality of the conference program.

The deadline for submission is August 1, 2008. 

Please click here to submit your proposal. 

For questions or suggestions about the meeting, please contact:
Edel O'Regan
Cambridge Healthtech Institute
250 First Avenue, Suite #300
Needham, MA 02494
Tel: 781-972-5423
Fax: 781-972-5425
email: eoregan@healthtech.com 

For sales information, contact:
Carol Dinerstein
Tel: 781-972-5471 
email: dinerstein@healthtech.com
OR
Jon Stroup
Tel: 781-972-5483
email: jstroup@healthtech.com